Nanoparticle Interactions with the Tumor Microenvironment

Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models.

PURPOSE Tumor cells are surrounded by a complex microenvironment. The purpose of our study was to evaluate the role of heterogeneity of the tumor microenvironment in the variability of nanoparticle (NP) delivery and efficacy. EXPERIMENTAL DESIGNS C3(1)-T-Antigen genetically engineered mouse model (C3-TAg) and T11/TP53(Null) orthotopic syngeneic murine transplant model (T11) representing human...

Imaging Tumor Microenvironment with Ultrasound

Recent advances in molecular biology are providing new opportunities for breast cancer imaging. Our approach uses ultrasound to image viscoelastic features of tumors. These features describe microenvironmental factors that stimulate signaling pathways in tumors that ultimately affect metastatic potential and response to traditional therapeutics. This paper explains the motivation for the approa...

Endothelial and Accessory Cell Interactions in Neuroblastoma Tumor Microenvironment

Transcriptional Analysis of Reciprocal Tumor-Microenvironment Interactions in Glioblastoma

vi Chapter 1: Introduction 1 Chapter 1 References 18 Chapter 2: Hitting Them Where They Live: Targeting the Glioblastoma Perivascular Stem Cell Niche 24 Chapter 2 References 42 Chapter 3: Methods of Transcriptional Analysis 50 Chapter 3 References 67 Chapter 4: Discovery of PDE7B as a novel effector of GBM growth by computational deconvolution of an in vitro physical 71 coculture system. Chapte...

The brain tumor microenvironment.

High-grade brain tumors are heterogeneous with respect to the composition of bona fide tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas harbor multiple cell types, some with increased tumorigenicity and stem cell-like capacity. The stem-like cells maybe the cells of origin for tumor relapse. However, the tumor-associated parenchymal cells such as vascula...